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Losartan is an angiotensin II receptor antagonist drug, which is mainly used to treat high blood pressure (hypertension).

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The aim of this trial was to evaluate the potential renoprotective capacity of direct renin inhibition with aliskiren in patients with hypertension, type 2 diabetes, and proteinuria who were already receiving the maximal recommended renoprotective treatment with losartan (100 mg daily) and optimal treatment for hypertension.

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Patients were required to stop taking such medications at least 24 hours prior to receiving the first dose of placebo in the run-in phase of the study.

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Fourteen percent of an oral dose is converted to an active carboxylic acid metabolite that is responsible for most of the angiotensin II receptor antagonist activity.

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It is important that the patient's overall health be assessed at each treatment visit and that any questions resulting from the patient's or their caregiver's reading of the patient labeling be discussed.

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