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Continuous positive airway pressure (CPAP) delivered by face mask reduced need for intubation and mechanical ventilation in patients with acute CHF, and this conclusion was validated in a recent meta-analysis ().
This drug is not indicated for initial therapy except when hypertension is severe enough that the benefit of achieving prompt blood pressure control exceeds the risk of initiating combination therapy.
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For all cuff blood pressure measurements, patients were seated for a minimum of 5 minutes before the first measurement.
We assigned participants once daily losartan-based or atenolol-based antihypertensive treatment for at least 4 years and until 1040 patients had a primary cardiovascular event (death, myocardial infarction, or stroke).
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We did find a significant difference in favor of losartan with regard to the rate of a first hospitalization for heart failure, a component of this secondary composite end point.
Losartan is an angiotensin II receptor antagonist drug, which is mainly used to treat high blood pressure (hypertension).
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In contrast, a large, randomized, controlled trial involving patients with type 2 diabetes, hypertension, and albuminuria who received the maximal recommended doses of ramipril and irbesartan failed to show a significant effect of combination therapy, as compared with monotherapy, on albuminuria, despite a significant reduction in systemic blood pressure.
During the screening phase, patients signed an informed consent agreement and a medical history was taken.
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Effect of Combination Therapy with the Angiotensin Receptor Blocker Losartan plus Hydrochlorothiazide on Brain Perfusion in Patients with both Hypertension and Cerebral Hemodynamic Impairment due to Symptomatic Chronic Major Cerebral Artery Steno-Occlusive Disease: A SPECT Study.
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The success of ARBs in the treatment of hypertension is reflected in the fact that six of these agents have been approved for this use since 1994.
Also listed are the International and Indian trade name(s) of the drug and its price list.
if blood pressure is not controlled by losartan alone a diuretic may be added in a low dose
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In the trial of this drug, reported on in 2003, a subgroup of diabetic patients taking the drug showed a 37 percent reduction in mortality from heart attacks or strokes and a 39 percent reduction in overall mortality over people on other treatment.
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The aim of this trial was to evaluate the potential renoprotective capacity of direct renin inhibition with aliskiren in patients with hypertension, type 2 diabetes, and proteinuria who were already receiving the maximal recommended renoprotective treatment with losartan (100 mg daily) and optimal treatment for hypertension.
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The active metabolite is 10 to 40 times more potent by weight than Losartan and appears to be a reversible, non-competitive inhibitor of the AT 1 receptor.
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Hydrochlorothiazide is a thiazide diuretic (water pill) that helps prevent your body from absorbing too much salt, which can cause fluid retention.
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Patients were required to stop taking such medications at least 24 hours prior to receiving the first dose of placebo in the run-in phase of the study.
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The Losartan Intervention For Endpoint reduction in hypertension (LIFE) study was a multinational, double-blind study comparing losartan and atenolol in 9193 hypertensive patients with ECG-documented left ventricular hypertrophy.
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As a result, a greater proportion of the patients on losartan potassium and hydrochlorothiazide tablets reached the target diastolic blood pressure (17.
Fourteen percent of an oral dose is converted to an active carboxylic acid metabolite that is responsible for most of the angiotensin II receptor antagonist activity.
ESRD, or death according to intention-to-treat (A) or per-protocol principal (B).
It is important that the patient's overall health be assessed at each treatment visit and that any questions resulting from the patient's or their caregiver's reading of the patient labeling be discussed.
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Meier Curves of the Percentage of Patients with the Primary Composite End Point (Panel A) and Its Individual Components, a Doubling of the Serum Creatinine Concentration (Panel B), End-Stage Renal Disease (Panel C), and the Combined End Point of End-Stage Renal Disease or Death (Panel D).
Losartan reduces albuminuria in patients with essential hypertension.
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